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Diagnosis of Dementia:Clinicopathologic Correlations Neurol 39:76-79, Boller,F.,et al, 1989 See this aricle in Pubmed Article Abstract Based on 54 demented patients consecutively autopsied at the University of Pittsburgh,we studied the accuracy of clinicians in predicting the pathologic diagnosis.Thirty-nine patients(72.2%)had Alzheimer's disease, while 15(27.7%)had other CNS diseases(four multi-infarct dementia;three Creutzfeldt-Jakob disease;two thalamic and subcortical gliosis;three Parkinson's disease;one progressive supranuclear palsy;one Huntington's disease;and one unclassified).Two neurologists independently reviewed the clinical records of each patient without knowledge of the patient's identity or clinical or pathologic diagnoses;each clinician reached a clinical diagnosis based on criteria derived from those of the NINCDS/ ADRDA.In 34(63%)cases both clinicians were correct,in nine(17%)one was correct,and in 11(20%)neither was correct.These results show that in patients with a clinical diagnosis of dementia,the etiology cannot be accurately predicted during life.

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(click to filter results - removes previous filter) Alzheimer's disease Alzheimer's disease,diagnosis of dementia dementia,clinical diagnosis dementia,differential diagnosis of neuropathology

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